Publications

  • N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling. Katarzyna W. Kliza, Wei Song, Irene Pinzuti, Simone Schaubeck, Simone Kunzelmann, David Kuntin, Arianna Fornili, Alessandro Pandini, Kay Hofmann, James A. Garnett, Benjamin Stieglitz, Koraljka Husnjak Cell Death Discov. 2024. 10(1):183.
  • Structural basis for ubiquitylation by HOIL-1. Wu Q, Koliopoulos MG, Rittinger K and Stieglitz B. Front. Mol. Biosci. 2023. 9:1098144: 10.3389/fmolb.2022.1098144
  • HHARI in motion reveals an unexpected substrate recognition site for RBR ligases. Stieglitz B. Structure 2022. 30;9: 1221-23
  • Ubiquitin Activation Is Essential for Schizont Maturation in Plasmodium Falciparum Blood-Stage Development. Green J.L., Wu Y., Encheva V., Lasonder E., Prommaban A., Kunzelmann S., Christodoulou E., Grainger M., Truongvan N, Bothe S., Sharma V., Song W., Pinzuti I., Uthaipibull C., Srichairatanakool S., Birault V., Langsley G., Schindelin H., Stieglitz B., Snijders A.P., Holder A.A. PLOS Pathogens 2020. 22;16(6)
  • Auxiliary-assisted chemical ubiquitylation of NEMO and linear extension by HOIP. Burlina F., Abdel-Aal A.-B.M., Raz R., Pinzuti I., Papageorgiou G., Li J., Antrobus R., Martin S.R., Kunzelmann S., Stieglitz B., Offer J. Communications Chemistry 2019. 2: 111
  • Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry. Kliza K., Taumer C., Pinzuti I., Franz-Wachtel M., Kunzelmann S., Stieglitz B., Macek B., Husnjak K. Nat Methods. 2017. 14:504-512
  • Determination of the pKa of the N-terminal amino group of ubiquitin by NMR. Oregioni A., Stieglitz B., Kelly G., Rittinger K., Frenkiel T. Sci Rep. 2017. 7:43748
  • Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms. Dove K.K., Stieglitz B., Duncan E.D., Rittinger K., Klevit R.E. EMBO Rep. 2016. 17:1221-35
  • Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Stieglitz B., Rana R.R., Koliopoulos M.G., Morris-Davies A.C., Schaeffer V., Christodoulou E., Howell S., Brown N.R., Dikic I., Rittinger K. Nature. 2013. 503:422-426
  • LUBAC synthesizes linear ubiquitin chains via a thioester intermediate. Stieglitz B., Morris-Davies A.C., Koliopoulos M.G.., Christodoulou E, Rittinger K. EMBO Rep. 2012. 13:840-6
  • Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold. Stieglitz B., Haire L.F., Dikic I., Rittinger K. J Biol Chem. 2012. 287:20823-9
  • Crystallization of SHARPIN using an automated two-dimensional grid screen for optimization. Stieglitz B., Rittinger K., Haire L.F. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. 68:816-9
  • SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Ikeda F., Deribe Y.L, Skånland S.S., Stieglitz B., Grabbe C., Franz-Wachtel M., van Wijk S.J., Goswami P., Nagy V., Terzic J., Tokunaga F., Androulidaki A., Nakagawa T., Pasparakis M., Iwai K., Sundberg J.P., Schaefer L., Rittinger K., Macek B., Dikic I. Nature. 2011. 471:637-41
  • An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Wilhelm C., Hirota K., Stieglitz B., Van Snick J., Tolaini M., Lahl K., Sparwasser T., Helmby H., Stockinger B. Nat Immunol. 2011. 12:1071-7.
  • Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation. Bee C., Moshnikova A., Mellor C.D., Molloy J.E., Koryakina Y., Stieglitz B., Khokhlatchev A., Herrmann C. J Biol Chem. 2010. 285:16258-66
  • Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. Stieglitz B., Bee C,. Schwarz D., Yildiz O., Moshnikova A., Khokhlatchev A., Herrmann C. EMBO J. 2008. 27:1995-2005
  • Crystal structure of the Clostridium limosum C3 exoenzyme. Vogelsgesang M., Stieglitz B., Herrmann C., Pautsch A., Aktories K. FEBS Lett. 2008. 582:1032-6